Selective Glucocorticoid Receptor Modulators: Future of Glucocorticoid Immunosuppressive Therapy?
نویسندگان
چکیده
منابع مشابه
Selective glucocorticoid receptor modulators: future of glucocorticoid immunosuppressive therapy?
In 1950 Hench, Kendall, and Reichstein received the Nobel Prize in Medicine for the characterization and isolation of glucocorticoids and the subsequent discovery of their antiinflammatory properties. To date, glucocorticoids are still widelyprescribedandplayanimportantrole inthetreatment of a variety of clinical disorders, including inflammatory diseases, autoimmune disorders, and hematologica...
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Glucocorticoids are widely used to suppress inflammation and treat various immune-mediated diseases. Some glucocorticoid receptor (GR)-regulated genes mediate the therapeutic response, whereas others cause debilitating side effects. To discover selective modulators of the GR response, we developed a high-throughput, multiplexed system to monitor regulation of 4 promoters simultaneously. An init...
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Glucocorticoids (GC) are the most common used anti-inflammatory and immunosuppressive drugs in the treatment of rheumatic and other inflammatory diseases. Their therapeutic effects are considered to be mediated by four different mechanisms of action: the classical genomic mechanism of action caused by the cytosolic glucocorticoid receptor (cGCR); secondary non-genomic effects which are also ini...
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Although adverse effects and glucocorticoid resistance cripple their chronic use, glucocorticoids form the mainstay therapy for acute and chronic inflammatory disorders, and play an important role in treatment protocols of both lymphoid malignancies and as adjuvant to stimulate therapy tolerability in various solid tumors. Glucocorticoid binding to their designate glucocorticoid receptor (GR), ...
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Corticosteroids secreted as end product of the hypothalamic-pituitary-adrenal axis act like a double-edged sword in the brain. The hormones coordinate appraisal processes and decision making during the initial phase of a stressful experience and promote subsequently cognitive performance underlying the management of stress adaptation. This action exerted by the steroids on the initiation and te...
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ژورنال
عنوان ژورنال: Endocrinology
سال: 2011
ISSN: 0013-7227,1945-7170
DOI: 10.1210/en.2011-1258